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. By focusing on the design strategies in mRNA engineering, we hope this Account will contribute to the rational design of synthetic mRNAs with broad therapeutic potential.The exploration for low-cost bifunctional materials for highly efficient overall water splitting has drawn profound research attention. Here, we present a facile preparation of Mo-P dual-doped Co/oxygen-deficient Co3O4 core-shell nanorods as a highly efficient electrocatalyst. In this strategy, oxygen vacancies are first generated in Co3O4 nanorods by lithium reduction