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ADHD Medications For Adults Stimulants help adjust levels of chemical messengers in the brain that regulate attention. They are considered first-line medications for ADHD. Although they are not to be taken regularly, they can have adverse effects like headaches and sleep problems. Your doctor may prescribe Guanfacine (brand names Tenex and Intuniv) or Clonidine (Catapres) to reduce hyperactivity and impulsivity. These drugs are more effective than stimulants. Stimulants Stimulants are the drugs that are most commonly pre