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g., degradation) and physical differences in the crystal formation, spatial distribution, morphology, and size. The production and deposition of test and reference materials remain critical to developing new technologies and detecting evolving threats.Glycation plays a pathogenic role in many age-related degenerative pathological conditions, such as diabetes, end-stage renal diseases, and cardiovascular diseases. Mass spectrometry-based qualitative and quantitative analysis methods have been greatly developed and contribute to our und