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However, the precise mechanisms are yet still to be disentangled. Due to the fact that majority of the effects ascribed to nanomaterials seems to induce disordered signalling, these interactions cannot stay neglected. A better understanding of signalling modulations induced by nanomaterials is not only essential for the accurate assessment of their toxicity, but also for synthesis and design of novel, safer nanomaterials.The family GH11 Aspergillus niger JL15 xylanase B (AnXylB11) was heterologously expressed in Pichia pastoris X33. Th