https://www.selleckchem.com/products/SGI-1776.html
Transcription suppressor Musculin (MSC) is enriched in pro-inflammatory Th17 and IL-22-producing ILC3s. While MSC+/+ mice survived DSS-induced colitis, MSC-/- mice showed elevated pro-inflammatory cytokines with severer pathology, reduced body weight, and earlier death. Reversal of colitis symptoms in MSC-/- mice by IL-22 antagonism suggests the existence of MSCIL-22 regulatory axis.The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by in
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