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copic treatment for type II EGJ neoplasm, however, it is time-consuming and has a higher rate of adverse events. Furthermore, EMR is a safe and alternative technique, particularly when EMR could achieve en bloc resection. We aimed to investigate the prevalence and prognostic role of ( ) amplification and expression in surgically resected esophageal squamous cell carcinoma (ESCC). We evaluated 450 ESCC samples using fluorescence in-situ hybridization and immunohistochemistry for gene amplification and protein expression, respectively. The re