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This research is designed to get insights into the inhibitory system of catechin derivatives epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG), and epigallocatechin gallate (EGCG) using in silico as well as in vitro researches specially deciding on NF-κB focusing on. We explored the binding pose, interacting deposits and molecular communications for catechin derivatives with NF-κB. Docking evaluation revealed tha