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Endoglin (CD105) will act as a coreceptor for changing development factor-β (TGF-β) signaling, and is overexpressed in tumor-associated endothelial cells and enhances cyst angiogenesis. Many clinical tests are testing the potency of anti-endoglin antibodies in various forms of malignancies. Right here, we investigated the role of endoglin within the pathogenesis of angiosarcoma and whether endoglin inhibition results in anti-tumor activity. Endoglin had been overexpre