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How Does Medication For ADHD Work? are the most commonly used ADHD medication prescribed. They increase the levels of brain chemicals, called dopamine and norepinephrine. They include methylphenidate (Ritalin, Concerta), amphetamine, dextroamphetamine (Adderall) and the lisdexafetamine (Vyvanse). They are usually prescribed in a long-release forms that last from six to eight hours, or more. This helps reduce the fluctuations and downs when the medicine wears out. This may reduce symptoms f