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istered for our prospective cohort studies after providing written informed consent (ClinicalTrials.gov NCT00822731 [date of registration - January 14, 2009] and NCT01877109 [date of registration - June 13, 2013]).Riboflavin (RF) and its active forms, the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), have been extensively used in the food, feed and pharmaceutical industries. Modern commercial production of riboflavin is based on microbial fermentation, but the established genetically engineered production s