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ADHD Treatment For Adults - Stimulant Medication Stimulant drugs like methylphenidate and dextroamphetamine are typically considered the first-line therapy for adult ADHD. These drugs regulate and boost levels of brain chemicals known as neurotransmitters. Nonstimulant and antidepressant medications like atomoxetine can be prescribed if stimulants aren't appropriate for the patient due to other health issues or adverse reactions. These dr