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This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.A 42-year-old woman with type 1 diabetes presents to her general practitioner (GP) with multiple skin lesions on the back of her hand, which have slowly grown in size (Fig. 1). This article is protected by copyright. All rights reserved.We sought to determine whether TDZD-8, the inhibitor of the glycogen synthase kinase-3β (GSK3β) can protect the synovial membrane of the knee joint against injuries induced by collagen