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RT-PCR was used for detection regarding the expression degree of miR-221-5p and DDR1. Wound recovery assay and CCK-8 assay were used for exploration of the cell migration and viability. Western blot and double luciferase reporter gene had been carried out to determine the target gene of miR-221-5p. Outcomes It was indicated that miR-221-5p appearance was diminished in GC tissues and mobile lines. The high expression of miR-221-5p reduced the resistance of