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Transmission electron microscopy (TEM) had been used to judge architectural alterations in mitochondria and mitochondrial DNA (mtDNA) copy number and mitochondrial membrane layer potential (MMP) were also taped. Eventually, we investigated the effects of VEGF upon mitochondrial biogenesis, autophagy and mitochondrial autophagy (mitophagy) as determined in both vivo as well as in vitro with western blots.Results VEGF treated mice showed improvements in spatial