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7% (17/104 of patients in periods I and II, respectively. Notably, the rate of late (6 months since last procedure) CIED infection was significantly increased in period II (1.3% vs. 0.1%, p less then 0.01), despite the rate of early infection (≤6 months) being comparable (0.4% vs. 0.6%, p = 0.58). On multiple logistic regression, revision [odds ratio (95% confidence interval) 5.2 (1.6-16.3), p = 0.005] and age [0.96, (0.93-0.99), p = 0.007] were identified as independent risk factors for CIED infection in period II. CONCLUSIONS O