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Maintaining extra DO amounts (10-40% DO) through DO-stat control while the substitution of GlcNAc at an assortment (5-20 g/L) with sugar (Glc) critically inspired HA production. DO-stat control method yielded a promising HA titer (2.4 g/L) at 40per cent DO focus. Managing DO amount at 20% (DO-stat) had been seen become optimum resulting in a significant HA production (2.1 g/L) as well as its molecular weight varying 0.98-1.45 MDa with a frequent polydispersity index (PDI) (1.57-1.69). Substitutio
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