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How Does Medication For ADHD Work? are among the most frequently prescribed ADHD medicines. They boost the levels brain chemicals called dopamine and norepinephrine. They include methylphenidate (Ritalin, Concerta), amphetamine, dextroamphetamine (Adderall) and lisdexafetamine (Vyvanse). Doctors typically prescribe these in long-release formulations that last six to eight hours or more. This reduces fluctuations and downs as the medication gets rid of. Most people can