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03; 95%CI 1.02-1.05) and higher % of sleep time with O saturation 90% (T9 (OR 1.02; 95%CI 1.00-1.03), were associated with PAE as determined by PAD. However, only T90 remained significantly associated with PAE as defined by the PAAo ratio (OR 1.02; 95%CI 1.01-1.03). In the subset group without OSA, only T90 remains associated with PAE, whether defined by PAD measurement (OR 1.02; 95%CI 1.01-1.03) or PAAo ratio (OR 1.04; 95%CI 1.01-1.07). In smokers with or without COPD, nocturnal hypoxemia was associated with PAE independently of