https://www.selleckchem.com/pr....oducts/sovilnesib.ht
Proteomic analysis using biotinylated mass spectrometry and RNAi screening also showed physical and functional interactions of SLFN11 with translation initiation complexes and protein folding machinery. These findings uncover a previously unknown function of SLFN11 as a regulator of protein quality control and attenuator of ER stress and UPR. Moreover, they suggest the potential value of TAK-243 in SLFN11-deficient tumors. SIGNIFICANCE This study uncovers that SLFN11 deficiency induces proteotoxic stress and sensitizes cancer cells t
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