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These causes disrupt lung barrier integrity, trigger proinflammatory mediator release, and differentially regulate genes and non-coding oligonucleotides including microRNAs. In this study, we identify miR-146a as a mechanosensitive microRNA in alveolar macrophages who has healing prospective to mitigate lung injury during mechanical ventilation. We utilize humanized in-vitro systems, mouse models, and biospecimens from customers to elucidate the appearance dynamics of miR-146a nece