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" The practitioners could understand the change of the public interest in facial rejuvenation in time and decide what to focus on. The public has a positive attitude toward facial rejuvenation during the pandemic. In particular, minimally invasive procedures dominate the mainstream, such as "Botox," "Hyaluronic acid," and "PRP." The practitioners could understand the change of the public interest in facial rejuvenation in time and decide what to focus on.The innate hypoxic microenvironment of most solid tumors has a major influence on t