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% (95% CI - 33, 6) compared to baseline. The 1,7-mRCTR approach significantly reduced the malaria burden in the areas of high transmission in rural southern Tanzania. This locally tailored approach could accelerate malaria control and elimination efforts. The results provide the impetus for further evaluation of the effectiveness and scaling up of this approach in other high malaria burden countries in Africa, including Tanzania. The 1,7-mRCTR approach significantly reduced the malaria burden in the areas of high transmission