https://www.selleckchem.com/pr....oducts/bi-1015550.ht
This strategy aims to achieve improved, persistent macro-chimerism as well as engraftment of BM across a xenogeneic barrier. The initial study published in 2015 demonstrated that this IBBMTx strategy leads to markedly prolonged peripheral macro-chimerism detectable for up to 23 days. Furthermore, a more recent study using human CD47-transgenic (Tg) GalTKO pigs as xeno-donors achieved long-lasting macro-chimerism 60 days with evidence of reduction of anti-pig natural antibodies (nAb). This is the longest macro-chimerism that has e
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