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Periodontitis is a chronic inflammatory and multifactorial disease that affects the periodontal structures and can cause alterations in the hepatic tissue. The aim of the present study was to evaluate whether a diet with food restriction can decrease oral and liver alterations associated with ligature-induced periodontitis. Twenty-four female Wistar rats were used in this study, randomized into three groups (n=8 for each group) control (regular food); periodontitis (regular food + periodontitis induced with ligatures); and food restrict