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Wheat productivity is threatened by global climate change. In several parts of NW Europe it will get warmer and dryer during the main crop growing period. The resulting likely lower realized on-farm crop yields must be kept by breeding for resistance against already existing and emerging diseases among other measures. Multi-disease resistance will get especially crucial. In this review, we focus on disease resistance breeding approaches in wheat, especially related to rust diseases and Fusarium head blight, because simulation studies of