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Evo inhibited the peak I Ca,L in colonic SMCs at a membrane potential of 0 mV. The current-voltage (I-V) commitment of L-type calcium channels had been changed by Evo, as the top of the I-V curve remained at 0 mV. Furthermore, Evo inhibited the activation of L-type calcium networks and reduced the peak we Ca,L. The relaxant aftereffect of Evo on colonic muscle mass is from the inhibition of L-type calcium stations. The enteric neurons, NO, and CCK1R may
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