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Antimalarial agents are necessary tools in the global malaria eradication agenda and plants used traditionally in the treatment of malaria are indispensable sources of antimalarial compounds. The aim of this study was to evaluate the antiplasmodial potential of Phyllanthus nivosus leaf. In vitro antiplasmodial assay was conducted using Plasmodium falciparum infected erythrocytes incubated at 37 °C in modified RPMI 1640 culture media. The inhibitory effect of the ethanol extract on plasmodium lactate dehydrogenase (pLDH) activity was determined as a measure