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The cyclic RGD peptides 1a-e exhibited IC50 of 9.9, 5.5, 72, 11 and 3.3 nM, respectively, towardsαvβ3 integrin protein. This finding offers further possibilities for the introduction strange proteins in to the cyclic peptide framework of cilengitide. Microalgae are autotroph organisms that utilise light power to synthesize different high-value bioactive compounds such polysaccharides, proteins and lipids. Due to its fast development rate and capability to survive in harsh en