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Across 16 adherence-related actions or health results such as lost to follow-up, retention in treatment, antiretroviral use, CD4 count, viral suppression, and mortality, 73% of studies contrasting YLH to other age groups (n = 106) discovered worse outcomes among YLH. In 22 researches, barriers and facilitators to adherence were identified, some unique to YLH (e.g., conflicting treatment objectives of providers) plus some common to other age ranges. Eventually, regarding the eight adherence treatm