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he impact of litigation. Keywords informed consent, malpractice, clinical negligence claims, litigation, otolaryngology.The thermodynamically unstable, colourless closed-ring isomer of spiropyran can be stabilized in water by the anti-configurational isomer of amide naphthotube. The influence of the binding on the thermodynamics and kinetics of spiropyran have been studied. The complex was further used to prepare a test paper that allows naked-eye detection of toxic paraoxon.Cellular responses to hypertonic stress and how these are linked