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The physical sign of tenderness may complement the symptoms of the Kansas criteria as a diagnostic criterion for GWI females, and aid in the diagnosis of CFS. Molecular mechanisms of systemic hyperalgesia may provide new insights into the neuropathology and treatments of these nociceptive, interoceptive and fatiguing illnesses.The breakup of a quantum liquid droplet is examined through a 4He cluster by removing the attractive tail in the interaction between some of the atoms in the system with the diffusion quantum Monte Carlo simulatio