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30%, OR 4.21, 95% CI 2.86 - 6.18), chronic pouchitis (47% vs. 15%, OR 6.37, 95% CI 3.41 - 11.9) and pouch failure (10% vs. 7%, OR 1.85, 95% CI 1.08 - 3.17). Patients with PSC-UC were more likely to experience pouchitis and pouch failure compared to UC alone. The risks of inflammatory complications after IPAA must be weighed against the potential complications with other surgical procedures, and future studies comparing outcomes among these procedures may inform decision making in this population. Patients with PSC-UC were more likely to