https://www.selleckchem.com/products/cpi-613.html
Mechanistically, a genome-wide CRISPR screen revealed that such a resistance mechanism is elicited by a dual axis GCN2-ATF4 aimed at restoring amino acid levels and MAPK-BCLXL to promote survival. Importantly, pharmacological inhibition of such nodes synergizes with l-asparaginase-mediated asparagine deprivation in ASNS deficient cells suggesting novel potential therapeutic combinations in melanoma.Despite being among the most characterized G protein-coupled receptors (GPCRs), adenosine receptors (ARs) have always been a difficult targe
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