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It suggested that Wnt/β-catenin was a key pathway of wogonin on colorectal disease. Then, pharmacology and molecular mechanism scientific studies had been performed according to network pharmacological outcomes. Pharmacological outcomes revealed that wogonin inhibited somewhat the expansion of SW480(P less then 0.001), with a concentration-dependent regularity when you look at the range of 12.5-50 μmol·L~(-1). Additionally, wogonin could cause G_1 phase blocking of SW480 cells. Western blot had been