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Background Retinopathy of prematurity (ROP) is a multifactorial retinal condition described as an abnormal vascular improvement the retina regarding the preterm infants. Carotenoids tend to be normal pigments which can be synthesized by all flowers and some microorganisms where they may play a role in photoprotection and coloration. Lutein and zeaxanthin (L/Z) are two carotenoids recognized as the most important the different parts of the macular pigm