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Such devices are developed for clinical applications such as the treatment of epilepsy, neuro-prostheses, and brain-machine interfacing for therapeutic purposes.Micro-electrode recording (MER) is a powerful way of localizing target structures during neurosurgical procedures such as the implantation of deep brain stimulation electrodes, which is a common treatment for Parkinson's disease and other neurological disorders. While Micro-electrode Recording (MER) provides adjunctive information to guidance assisted by pre-operative imaging,