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OBJECTIVE To analyze the relationship between the length from injury to first debridement (LFITFD) of open tibial fractures and perioperative infection, and explore independent risk factors related to infection. METHODS This retrospective study focused on 215 clinical patients with open tibial fractures who were admitted from January 2012 to January 2017. According to the time from injury to the operation, the patients were categorized into four groups LFITFD ≤ 6 h, 6 24 h). Infection risk factors were screened by univariate analysis, and