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We suggest considering the risk/benefit when administration naloxone, especially for the seizure risk factors including previous history of seizure, tramadol misuse, and co-ingestion. Copyright © 2019 International Journal of Preventive Medicine.Background To test whether gender moderates the effects of baseline depressive symptoms and chronic medical conditions (CMCs) on risk of receiving subsequent psychiatric diagnosis among older adults. Methods Data came from ten waves of the Health and Retirement Study, a nationally rep