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A new grammar is constructed based on this integration. Results of the MOGGP model discovery process find new hybrid models that outperform the existing single-theory models and the baseline hybrid model. Future work should consider and further refine the role of domain experts in defining the meaningfulness of models identified by MOGGP.Macrophages play a crucial role in host innate immune defense against infection and tissue injury. Although macrophage activation and polarization has been well studied, we know less regarding the role