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will be discussed in relation to the research questions using a narrative to identify and explore emergent themes. The review will provide a baseline of evidence on exercise and physical activity interventions for OPLWH. It will highlight gaps regarding the use of exercise and physical activity and contribute to the design of an effective intervention approach to the rehabilitation of OPLWH. SYSTEMATIC REVIEW REGISTRATION Open Science Framework (https//osf.io/728kp/).BACKGROUND Early-life stress (ES) is an emerging risk factor for late