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Hemolysis induced an overestimation of PON-1 activity; lipemia and hyperbilirubinemia did not change PON-1 activity. Thirty-four horses were sampled monthly for 1 y, and PON-1 activity was higher in autumn (p less then 0.05) and winter (p less then 0.05) than in spring and summer.Aim The current study aimed to explore the feasibility of the nanoemulgel for the topical delivery of aceclofenac. Materials methods Solubility of drugs in the formulation systems was determined and aceclofenac nanoemulsion (NE) was prepared by high-pressur