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We study the sensitivity and practicality of Henderson's theorem in classical statistical mechanics, which states that the pair potential v(r) that gives rise to a given pair correlation function g2(r) [or equivalently, the structure factor S(k)] in a classical many-body system at number density ρ and temperature T is unique up to an additive constant. While widely invoked in inverse-problem studies, the utility of the theorem has not been quantitatively scrutinized to any large degree. We show that Henderson's theorem has practical shortc