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Medication For ADHD - What Are the Side Effects? Many people with ADHD experience a reduction in symptoms when taking medication. But every person reacts differently to different drugs and side effects can be troublesome. Methylphenidate is a stimulant. It increases the levels of a chemical in the brain that regulates behavior and attention. Stimulant drugs Stimulant medications enhance attention and concentration in 70% to 80% of adults and children who take them. They affect neurotransmitters such as norepinephrine and dopamine in the br