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The apoptosis of renal tubular epithelial cells (TECs) during ischemia/reperfusion (I/R) facilitates the progression of acute kidney injury (AKI). This study aimed to probe the role of long noncoding RNA maternally expressed 3 (MEG3) in I/R-induced apoptosis of TECs. In this study, with CoCl2 and hypoxia/reoxygenation treatments, cell models were established to mimic I/R using the human kidney tubular cell line HK-2. In HK-2 cells, expression of MEG3 detected using quantitative real-time polymerase chain reaction (qRT-PCR), was significa