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s treated with SBRT, CBCT radiomics could be another effective method. © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley Sons Australia, Ltd.BACKGROUND CD73 induces the dephosphorylation of adenosine monophosphate converting it to adenosine, enabling malignancies to escape from immune surveillance. Although CD73 overexpression has been reported to be a poor prognostic factor in several malignancies including non-small cell lung cancer (NSCLC), its predictive relevance in NSCLC patients re