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All progression criteria established for continuation of the study were met. Pilot data indicate preliminary demonstration of feasibility and acceptability of a fully digital pathway for BRCA-testing and support proceeding to a full powered study for evaluation of non-inferiority of the fully digital pathway, detailed quantitative assessment of outcomes and operational economic analyses. ISRCTN87845055. ISRCTN87845055.This first of two practice reviews addresses pulmonary embolism (PE) diagnosis considering important aspects of PE clinical presentat