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This article provides an overview of the incidence and prevalence of sexually transmitted infections in pregnant women in the United States. It discusses screening guidelines and best practices related to treatments. Safety, pharmacology, and monitoring of both the woman and her fetus are detailed.There is a need to increase improve the delivery of health care for sexual minorities. The lesbian, gay, bisexual, transgender, and queer (LGBTQ) community has historically experienced bias, discrimination, and perceived inadequate or inappropr