https://www.selleckchem.com/pr....oducts/gw806742x.htm
Additionally, [Ca2+]i levels in HEK293 cells with CaSR-WT and CaSR-Y825F were determined at 340 nm/380 nm wavelength ratios using Fura-2 AM. At [Ca2+]e concentrations of 2.5 mM and 3 mM, the ratios of CaSR-Y825F cells were higher (2.6 and 3.5, respectively) than those of CaSR-WT cells, which were 1.04 and 1.40, respectively. This cell function study proved that the CaSR-Y825F, which is in HEK293 cells transformed with a activating CaSR variant, elevated MAP kinase signaling(pERK, pJNK, pp38) and increased [Ca2 +] i to induce hypocalce
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