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STUDY OBJECTIVES There are few studies evaluating 1. exercise capacity, as assessed by the six minutes walking distance test (6MWD) in large populations with obstructive sleep apnea (OSA); 2. correlations with patients' comorbidities. METHODS Cluster analysis on data of 1228 patients. Severity of exercise limitation was defined on the basis of 6MWD. RESULTS Sixty-one % showed exercise limitation (29.2 % and 31.9 % mild and severe exercise limitation, respectively). About 60 and 40 % of patients were included in cluster 1 (CL1) and 2 (CL