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The SCCHN is a heterogeneous number of types of cancer for the mouth area, the pharynx and also the larynx with poor prognosis despite the aggressive multimodal treatments. In the past decade, significant improvements had been manufactured in knowledge of the molecular and genetic abnormalities leading to oncogenesis in SCCHN. RECENT FINDINGS Besides EGFR targeting agents, antiangiogenic agents happen proven to produce antitumor task in these tumors.